Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics
민승기, 정주희, 안강민, 유종우, 박주용, 최성원,
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민승기 ( Min Seung-Ki ) - National Cancer Center Research Institute and Hospital Oral Oncology Clinic
정주희 ( Jeong Joo-Hee ) - National Cancer Center Research Institute and Hospital Oral Oncology Clinic
안강민 ( Ahn Kang-Min ) - University of Ulsan College of Medicine Asan Medical Center Department of Oral and Maxillofacial Surgery
유종우 ( Yoo Chong-Woo ) - National Cancer Center Department of Pathology
박주용 ( Park Joo-Yong ) - National Cancer Center Research Institute and Hospital Oral Oncology Clinic
최성원 ( Choi Sung-Weon ) - National Cancer Center Research Institute and Hospital Oral Oncology Clinic
Abstract
Objectives: Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review.
Materials and Methods: We analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology, treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method.
Results: Initial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment was possible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survival rate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%.
Conclusion: Oral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosis and adequate surgery may result in improved overall survival.
키워드
Oral desmoplastic melanoma; Diagnosis; Recurrence; Survival
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